Journal: PLoS Computational Biology

Article Title: Quantifying Differences and Similarities in Whole-Brain White Matter Architecture Using Local Connectome Fingerprints

doi: 10.1371/journal.pcbi.1005203

Figure Lengend Snippet: (A) The spin distribution function (SDF) calculated from diffusion MRI quantifies the density of diffusing water along axonal fiber bundles. The magnitudes of the SDF at axonal directions provide density-based measurements to characterize axonal fiber bundles. (B) The density measurements obtained from the SDFs show individuality between-subjects #1, #2, and #3 (intensity scaled between [0 0.8]). The density of diffusing water varies substantially across different portions of the corpus callosum. The repeat measurements after 238 (subject #1), 191 (subject #2), and 198 (subject #3) days present a consistent pattern that captures individual variability. (C) In contrast to the SDF shown in (B), the fractional anisotropy derived from diffusivity shows no obvious individuality between the same subjects #1, #2, and #3 (intensity also scaled between [0 0.8]). This is due to the fact that diffusivity, which quantifies how fast water diffuses, does not vary a lot in normal axonal bundles.

Article Snippet: Each subject had three diffusion MRI scans within 16 days on a Siemens Trio 3T system at the University of California, Santa Barbara.

Techniques: Diffusion-based Assay, Derivative Assay

Journal: PLoS Computational Biology

Article Title: Quantifying Differences and Similarities in Whole-Brain White Matter Architecture Using Local Connectome Fingerprints

doi: 10.1371/journal.pcbi.1005203

Figure Lengend Snippet: (A) Local connectome fingerprinting is conducted by first reconstructing diffusion MRI data into a standard space to calculate the spin distribution functions (SDFs). A common fiber direction atlas is then used to sample the density of diffusing water along the fiber directions in the cerebral white matter. The sampled measurements are compiled in a left-posterior-superior order to form a sequence of characteristic values as the local connectome fingerprint. (B) One local connectome fingerprint is shown in different zoom-in resolutions. A local connectome fingerprint has a total of 513,316 entries of scalar values. (C) The local connectome fingerprint of subject #1, #2, and #3 and their repeat measurements (lower row) after 238, 191, and 198 days, respectively. At a coarse level, the local connectome fingerprint differs substantially between three subjects, whereas those from the repeat scans show a remarkably identical pattern, indicating the uniqueness and reproducibility of the local connectome fingerprint.

Article Snippet: Each subject had three diffusion MRI scans within 16 days on a Siemens Trio 3T system at the University of California, Santa Barbara.

Techniques: Diffusion-based Assay, Sequencing

Journal: BMC Infectious Diseases

Article Title: Clinical outcomes in patients co-infected with COVID-19 and Staphylococcus aureus : a scoping review

doi: 10.1186/s12879-021-06616-4

Figure Lengend Snippet: Clinical characteristics

Article Snippet: Rajdev , 1 , MSSA , Tracheal aspirate, pneumonia , Hospital-onset , Fever, cough, dyspnea, myalgias , Diffuse bilateral pulmonary opacities on CXR , Antibiotics, intubation and ventilation, corticosteroids, tacrolimus, mycophenolate, remdesivir , Hypoxic respiratory failure, Guillan Barré syndrome , 23 , NR , Discharge.

Techniques: Computed Tomography, Blocking Assay, Magnetic Resonance Imaging, Transformation Assay